Compound Detail
CHEMBL383662
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Basic Information
| ChEMBL ID | CHEMBL383662 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZHVOBYUGDXIPLT-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
335.4
MW (Da)
5.17
ALogP
5
HBA
2
HBD
62.6
PSA (Ų)
0.54
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.05
Ki 1 meas. best 6.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 6.43 | 6.43 | 368.0 | 1 |
| L cells CHEMBL612266 | IC50 | 4.05 | 4.05 | 89200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | Ki | = | 368.0 | nM | 6.43 | Inhibition of [3H]glycine binding to NMDA receptor in rat brain membranes | 16451052 |
| L cells | IC50 | = | 89200.0 | nM | 4.05 | Cytotoxicity against mouse fibroblast L(tk-) cells transfected with human NMDA u... | 16451052 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16451052 | 10.1021/jm0503493 | Glutamate NMDA receptor | 1 |
| 16451052 | 10.1021/jm0503493 | L cells | 1 |
Data from ChEMBL 36 via Core Engine