Assay Detail
Functional
CHEMBL853654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against Leishmania donovani DI700 promastigotes
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 18 | - | - |
| EC50 | 13 | 5.25 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556966 | — | — | 1 | 6.40 |
| CHEMBL541379 | — | — | 1 | 6.30 |
| CHEMBL537017 | — | — | 1 | 6.16 |
| CHEMBL536066 | — | — | 1 | 5.19 |
| CHEMBL541381 | — | — | 1 | 5.05 |
| CHEMBL541380 | — | — | 1 | 5.05 |
| CHEMBL381751 | — | — | 1 | 4.40 |
| CHEMBL222838 | EFLORNITHINE, (S)- | 2.0 | 1 | 4.40 |
| CHEMBL556965 | — | — | 1 | 4.30 |
| CHEMBL536067 | — | — | 1 | - |
| CHEMBL541638 | — | — | 1 | - |
| CHEMBL535621 | — | — | 1 | - |
| CHEMBL222968 | — | — | 1 | - |
| CHEMBL556967 | — | — | 1 | - |
| CHEMBL536065 | — | — | 1 | - |
| CHEMBL373659 | — | — | 1 | - |
| CHEMBL13968 | BUTYLAMINE | — | 1 | - |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | - |
| CHEMBL35241 | DIMINAZENE | 2.0 | 1 | - |
| CHEMBL535620 | — | — | 1 | - |
| CHEMBL222889 | — | — | 1 | - |
| CHEMBL1790048 | — | — | 1 | - |
| CHEMBL536291 | — | — | 1 | - |
| CHEMBL536553 | — | — | 1 | - |
| CHEMBL536502 | — | — | 1 | - |
| CHEMBL535841 | — | — | 1 | - |
| CHEMBL558372 | — | — | 1 | - |
| CHEMBL538082 | — | — | 1 | - |
| CHEMBL536064 | — | — | 1 | - |
| CHEMBL536068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556966 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL541379 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL537017 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL536066 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL541381 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL541380 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL381751 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL222838 | EFLORNITHINE, (S)- | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL556965 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL536067 | — | Activity | - | — | - | |
| CHEMBL216913 | MITOGUAZONE | EC50 | = | 1800000.0 | nM | - |
| CHEMBL541638 | — | Activity | - | — | - | |
| CHEMBL535621 | — | Activity | - | — | - | |
| CHEMBL222968 | — | Activity | - | — | - | |
| CHEMBL556967 | — | Activity | - | — | - | |
| CHEMBL536065 | — | Activity | - | — | - | |
| CHEMBL373659 | — | Activity | - | — | - | |
| CHEMBL13968 | BUTYLAMINE | EC50 | = | 400000.0 | nM | - |
| CHEMBL55 | PENTAMIDINE | EC50 | = | 1900000.0 | nM | - |
| CHEMBL35241 | DIMINAZENE | EC50 | = | 9500000.0 | nM | - |
| CHEMBL535620 | — | Activity | - | — | - | |
| CHEMBL222889 | — | Activity | - | — | - | |
| CHEMBL1790048 | — | Activity | - | — | - | |
| CHEMBL536291 | — | Activity | - | — | - | |
| CHEMBL536553 | — | Activity | - | — | - | |
| CHEMBL536502 | — | Activity | - | — | - | |
| CHEMBL535841 | — | Activity | - | — | - | |
| CHEMBL558372 | — | Activity | - | — | - | |
| CHEMBL538082 | — | Activity | - | — | - | |
| CHEMBL536064 | — | Activity | - | — | - | |
| CHEMBL536068 | — | Activity | - | — | - |