Assay Detail
Binding
CHEMBL854092
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Binding to human 5HT2B receptor expressed in CHO cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.53 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201930 | — | — | 1 | 8.96 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.82 |
| CHEMBL201454 | — | — | 1 | 8.68 |
| CHEMBL76781 | — | — | 1 | 8.37 |
| CHEMBL202458 | — | — | 1 | 7.70 |
| CHEMBL202616 | — | — | 1 | 7.57 |
| CHEMBL202538 | — | — | 1 | 7.36 |
| CHEMBL201062 | — | — | 1 | 7.35 |
| CHEMBL201897 | — | — | 1 | 7.21 |
| CHEMBL202324 | — | — | 1 | 7.04 |
| CHEMBL380763 | — | — | 1 | 7.01 |
| CHEMBL379223 | — | — | 1 | 6.89 |
| CHEMBL201117 | — | — | 1 | 6.89 |
| CHEMBL202656 | — | — | 1 | 6.82 |
| CHEMBL383042 | — | — | 1 | 6.33 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201930 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL39 | SEROTONIN | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL201454 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL76781 | — | EC50 | = | 4.3 | nM | 8.37 |
| CHEMBL202458 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL202616 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL202538 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL201062 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL201897 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL202324 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL380763 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL379223 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL201117 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL202656 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL383042 | — | EC50 | = | 462.0 | nM | 6.33 |
| CHEMBL478 | CHLOROPHENYLPIPERAZINE | EC50 | > | 1000.0 | nM | - |