Compound Detail
CHEMBL201117
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Basic Information
| ChEMBL ID | CHEMBL201117 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WKHUJGFKHHPASV-INIZCTEOSA-N |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
321.5
MW (Da)
4.75
ALogP
3
HBA
1
HBD
29.9
PSA (Ų)
0.73
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.11
EC50 2 meas. best 6.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 7.11 | 7.11 | 78.0 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | EC50 | 6.89 | 6.89 | 128.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | EC50 | 6.46 | 6.46 | 348.0 | 1 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | Ki | 6.21 | 6.21 | 624.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 6.03 | 6.03 | 927.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C | Ki | = | 78.0 | nM | 7.11 | Displacement of [3H]5-HT from human 5HT2C | 16257207 |
| 5-hydroxytryptamine receptor 2B | EC50 | = | 128.0 | nM | 6.89 | Binding to human 5HT2B receptor expressed in CHO cells | 16257207 |
| 5-hydroxytryptamine receptor 2C | EC50 | = | 348.0 | nM | 6.46 | Binding to human 5HT2C receptor expressed in CHO cells | 16257207 |
| 5-hydroxytryptamine receptor 2B | Ki | = | 624.0 | nM | 6.21 | Displacement of [3H]5-HT from human 5HT2B | 16257207 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 927.0 | nM | 6.03 | Displacement of [125I]DOI from human 5HT2A | 16257207 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16257207 | 10.1016/j.bmcl.2005.10.029 | 5-hydroxytryptamine receptor 2A | 3 |
| 16257207 | 10.1016/j.bmcl.2005.10.029 | 5-hydroxytryptamine receptor 2B | 3 |
| 16257207 | 10.1016/j.bmcl.2005.10.029 | 5-hydroxytryptamine receptor 2C | 3 |
Data from ChEMBL 36 via Core Engine