Assay Detail
Binding
CHEMBL854558
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Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorphinones and codeinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 9.27 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113666 | — | — | 1 | 9.82 |
| CHEMBL607068 | — | — | 1 | 9.70 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.70 |
| CHEMBL607125 | — | — | 1 | 9.68 |
| CHEMBL607018 | — | — | 1 | 9.47 |
| CHEMBL607126 | — | — | 1 | 9.46 |
| CHEMBL607017 | — | — | 1 | 9.40 |
| CHEMBL607127 | — | — | 1 | 9.31 |
| CHEMBL607069 | — | — | 1 | 9.22 |
| CHEMBL607016 | — | — | 1 | 9.17 |
| CHEMBL611402 | — | — | 1 | 9.15 |
| CHEMBL610883 | — | — | 1 | 9.14 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.96 |
| CHEMBL386492 | CLOCINNAMOX | — | 1 | 8.53 |
| CHEMBL386272 | — | — | 1 | 8.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113666 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL607068 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL607125 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL607018 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL607126 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL607017 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL607127 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL607069 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL607016 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL611402 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL610883 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL70 | MORPHINE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL386492 | CLOCINNAMOX | Ki | = | 2.98 | nM | 8.53 |
| CHEMBL386272 | — | Ki | = | 4.78 | nM | 8.32 |