Assay Detail
Functional
CHEMBL855009
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Antiproliferative activity against human DU145 cells after 72 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of carbazole sulfonamides as a novel class of antimitotic agents against solid tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.89 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.03 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.28 |
| CHEMBL385606 | — | — | 1 | 6.84 |
| CHEMBL216879 | — | — | 1 | 6.77 |
| CHEMBL216767 | — | — | 1 | 6.63 |
| CHEMBL216846 | — | — | 1 | 6.44 |
| CHEMBL437336 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL61 | PODOFILOX | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL385606 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL216879 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL216767 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL216846 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL437336 | — | IC50 | = | 603.0 | nM | 6.22 |