Assay Detail
Binding
CHEMBL855468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Ile5,6-deltorphin from delta opioid receptor in Wistar rat brain membrane
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.65 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219482 | — | — | 1 | 9.32 |
| CHEMBL2371935 | — | — | 1 | 9.21 |
| CHEMBL191751 | — | — | 1 | 8.91 |
| CHEMBL376453 | — | — | 1 | 8.82 |
| CHEMBL375095 | — | — | 1 | 8.70 |
| CHEMBL375094 | — | — | 1 | 8.70 |
| CHEMBL269314 | — | — | 1 | 8.40 |
| CHEMBL415426 | — | — | 1 | 8.39 |
| CHEMBL218782 | — | — | 1 | 8.15 |
| CHEMBL218781 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219482 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL2371935 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL191751 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL376453 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL375095 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL375094 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL269314 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL415426 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL218782 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL218781 | — | Ki | = | 13.0 | nM | 7.89 |