Assay Detail
Functional
CHEMBL855634
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Growth inhibition of DU145 cells by crystal violet assay after 24 hrs
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and preliminary evaluation of doxazolidine carbamates as prodrugs activated by carboxylesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.58 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.50 |
| CHEMBL384220 | — | — | 1 | 6.70 |
| CHEMBL214810 | — | — | 1 | 6.40 |
| CHEMBL214168 | — | — | 1 | 6.30 |
| CHEMBL384221 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL384220 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL214810 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL214168 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL384221 | — | IC50 | = | 1000.0 | nM | 6.00 |