Assay Detail
Functional
CHEMBL855843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombus formation in iv dosed rabbit arterio-venous shunt model
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.51 | 6.54 |
| ID50 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438647 | — | — | 2 | 6.54 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | -1.0 | 2 | 6.47 |
| CHEMBL213865 | — | — | 2 | - |
| CHEMBL386463 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438647 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL213865 | — | IC50 | - | — | - | |
| CHEMBL213865 | — | ID50 | = | 2.0 | umol/kg/hr | - |
| CHEMBL438647 | — | ID50 | = | 1.9 | umol/kg/hr | - |
| CHEMBL386463 | — | IC50 | - | — | - | |
| CHEMBL386463 | — | ID50 | = | 2.4 | umol/kg/hr | - |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | ID50 | = | 1.6 | umol/kg/hr | - |