Assay Detail
Functional
CHEMBL856201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of LTB4 biosynthesis in Ca++ ionophore activated human polymorphonuclear (HPMN) leukocytes.
31
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.34 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38958 | — | — | 1 | 8.70 |
| CHEMBL82760 | — | — | 1 | 8.70 |
| CHEMBL78013 | — | — | 1 | 8.70 |
| CHEMBL2114162 | — | — | 1 | 8.70 |
| CHEMBL433133 | — | — | 1 | 8.52 |
| CHEMBL78201 | — | — | 1 | 8.52 |
| CHEMBL39617 | — | — | 1 | 8.52 |
| CHEMBL3350287 | — | — | 1 | 8.52 |
| CHEMBL310384 | — | — | 1 | 8.52 |
| CHEMBL289751 | — | — | 1 | 8.52 |
| CHEMBL38545 | — | — | 1 | 8.52 |
| CHEMBL80287 | — | — | 1 | 8.52 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 8.40 |
| CHEMBL81904 | — | — | 1 | 8.40 |
| CHEMBL80512 | — | — | 1 | 8.40 |
| CHEMBL80696 | — | — | 1 | 8.40 |
| CHEMBL79383 | — | — | 1 | 8.40 |
| CHEMBL78938 | — | — | 3 | 8.30 |
| CHEMBL80726 | — | — | 1 | 8.22 |
| CHEMBL39473 | — | — | 1 | 8.22 |
| CHEMBL78789 | — | — | 1 | 8.22 |
| CHEMBL79881 | — | — | 1 | 8.15 |
| CHEMBL311968 | — | — | 1 | 8.10 |
| CHEMBL40073 | — | — | 1 | 8.10 |
| CHEMBL80158 | — | — | 1 | 7.92 |
| CHEMBL310055 | — | — | 1 | 7.66 |
| CHEMBL78854 | — | — | 1 | - |
| CHEMBL80802 | — | — | 1 | - |
| CHEMBL310276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38958 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL78013 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL82760 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2114162 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL433133 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL78201 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL38545 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL39617 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL80287 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3350287 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL310384 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL289751 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL79383 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL81904 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL80512 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL16596 | QUIFLAPON | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL80696 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL78938 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL80726 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL39473 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL78789 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL79881 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL40073 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL311968 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL78938 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL80158 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL310055 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL78938 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL78854 | — | IC50 | < | 7.0 | nM | - |
| CHEMBL310276 | — | IC50 | > | 18.0 | nM | - |
| CHEMBL80802 | — | IC50 | > | 52.0 | nM | - |