Assay Detail

CHEMBL856470

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ADMET

Cytotoxicity against Jurkat cells after 24 hrs by MTT assay

ChEMBL ↗

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Target

Jurkat (CHEMBL397) ↗

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Primary target Jurkat

CHEMBL397

Anchored from Assay target.

Protein identity Jurkat

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Cell Type	Jurkat
Confidence	1 — Organism
Curated By	Autocuration

Target

Jurkat (CHEMBL397) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

2-(3-Amino-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide: a new tiazofurin analogue with potent antitumour activity.

Popsavin M, Spaić S, Svircev M, Kojić V, Bogdanović G, Popsavin V.
Bioorg Med Chem Lett (2006) 16 : 5317 -5320
PubMed 16908146 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	6.81	7.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL219331	—	—	1	7.22
CHEMBL108358	TIAZOFURIN	2.0	1	6.85
CHEMBL375197	—	—	1	6.35

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL219331	—	IC50	=	60.0	nM	7.22
CHEMBL108358	TIAZOFURIN	IC50	=	140.0	nM	6.85
CHEMBL375197	—	IC50	=	450.0	nM	6.35