Assay Detail
Binding
CHEMBL856756
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Inhibitory constant against fetal bovine serum (FBS) acetylcholinesterase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.49 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.62 |
| CHEMBL39918 | — | — | 1 | 6.66 |
| CHEMBL37105 | — | — | 1 | 6.40 |
| CHEMBL245079 | HUPERZINE B | — | 1 | 6.10 |
| CHEMBL290113 | — | — | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395280 | HUPERZINE A | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL39918 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL37105 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL245079 | HUPERZINE B | Ki | = | 794.0 | nM | 6.10 |
| CHEMBL290113 | — | Ki | = | 2050.0 | nM | 5.69 |