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Compound Detail

CHEMBL290113

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CC1=CC2Cc3nc(O)ccc3C3(C1)NCCC(C)=C23

Basic Information

ChEMBL ID CHEMBL290113
Phase Preclinical
Structure Type MOL
InChI Key OBAHRUDJHVVJQM-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

268.4
MW (Da)
2.81
ALogP
3
HBA
2
HBD
45.1
PSA (Ų)
0.71
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H20N2O
MW 268.36
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness 1.01

Activity Summary

Ki 1 meas. best 5.69

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL4768
Ki 5.69 5.69 2050.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Acetylcholinesterase Ki = 2050.0 nM 5.69 Inhibitory constant against fetal bovine serum (FBS) acetylcholinesterase 12031333

Literature References

PubMed DOI Target Context # Activities
12031333 10.1016/s0960-894x(02)00204-4 Acetylcholinesterase 1

Data from ChEMBL 36 via Core Engine