Assay Detail
Functional
CHEMBL857025
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Functional activity was determined by the contraction of New Zealand white rabbit saphenous vein.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Saphenous vein |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.45 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54265 | — | — | 1 | 7.20 |
| CHEMBL53764 | — | — | 1 | 6.80 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.80 |
| CHEMBL53467 | — | — | 1 | 6.70 |
| CHEMBL53485 | — | — | 1 | 6.70 |
| CHEMBL53128 | — | — | 1 | 6.60 |
| CHEMBL905 | RIZATRIPTAN | 4.0 | 1 | 6.60 |
| CHEMBL50834 | — | — | 1 | 6.40 |
| CHEMBL52912 | — | — | 1 | 6.30 |
| CHEMBL39243 | — | — | 1 | 6.30 |
| CHEMBL299213 | — | — | 1 | 6.20 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 6.20 |
| CHEMBL52264 | — | — | 1 | 6.20 |
| CHEMBL53349 | — | — | 1 | 6.20 |
| CHEMBL298544 | — | — | 1 | 6.00 |
| CHEMBL50837 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54265 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL53764 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL39 | SEROTONIN | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL53467 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL53485 | — | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL53128 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL905 | RIZATRIPTAN | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL50834 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL52912 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL39243 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL299213 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL128 | SUMATRIPTAN | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL52264 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL53349 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL298544 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL50837 | — | EC50 | = | 1000.0 | nM | 6.00 |