Assay Detail
Functional
CHEMBL857029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for the alpha-1 adrenergic receptor antagonistic activity in rat vas deferens vs methoxamine alpha-1 adrenoceptor antagonism
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.56 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41720 | — | — | 1 | 8.03 |
| CHEMBL416072 | — | — | 1 | 8.02 |
| CHEMBL38829 | — | — | 1 | 7.75 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41720 | — | Kd | = | 9.333 | nM | 8.03 |
| CHEMBL416072 | — | Kd | = | 9.55 | nM | 8.02 |
| CHEMBL38829 | — | Kd | = | 17.78 | nM | 7.75 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 380.19 | nM | 6.42 |