Assay Detail
Functional
CHEMBL857044
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Inhibition of isoproterenol-induced responses in guinea pig trachea.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Ultra-short-acting beta-adrenergic receptor blocking agents. 3. Ethylenediamine derivatives of (aryloxy)propanolamines having esters on the aryl function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 22 | 7.86 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13110 | — | — | 1 | 9.30 |
| CHEMBL13228 | — | — | 1 | 9.10 |
| CHEMBL13111 | — | — | 1 | 9.00 |
| CHEMBL13365 | — | — | 1 | 8.90 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 8.90 |
| CHEMBL12748 | — | — | 1 | 8.80 |
| CHEMBL12984 | — | — | 1 | 8.50 |
| CHEMBL6920 | — | — | 1 | 8.20 |
| CHEMBL268715 | — | — | 1 | 8.20 |
| CHEMBL13284 | — | — | 1 | 7.90 |
| CHEMBL12903 | — | — | 1 | 7.70 |
| CHEMBL13666 | — | — | 1 | 7.70 |
| CHEMBL12657 | — | — | 1 | 7.70 |
| CHEMBL273930 | — | — | 1 | 7.70 |
| CHEMBL13384 | — | — | 1 | 7.50 |
| CHEMBL12873 | — | — | 1 | 7.30 |
| CHEMBL276385 | — | — | 1 | 7.10 |
| CHEMBL13358 | — | — | 1 | 7.10 |
| CHEMBL13098 | — | — | 1 | 7.10 |
| CHEMBL13131 | — | — | 1 | 7.00 |
| CHEMBL13299 | — | — | 1 | 6.70 |
| CHEMBL13504 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13110 | — | Kd | = | 0.5012 | nM | 9.30 |
| CHEMBL13228 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL13111 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL13365 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL27 | PROPRANOLOL | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL12748 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL12984 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL6920 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL268715 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL13284 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL12903 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL13666 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL12657 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL273930 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL13384 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL12873 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL276385 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL13358 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL13098 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL13131 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL13299 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL13504 | — | Kd | = | 3162.28 | nM | 5.50 |