Assay Detail
Functional
CHEMBL857131
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its agonist activity against M3-acetylcholine receptor of guinea pig ileum.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL5498) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
N alpha-alkylated derivatives of 2-phenylhistamines: synthesis and in vitro activity of potent histamine H1-receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 4.31 | 4.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314438 | — | — | 1 | 4.57 |
| CHEMBL313301 | — | — | 1 | 4.19 |
| CHEMBL88074 | — | — | 1 | 4.16 |
| CHEMBL24665 | — | — | 1 | - |
| CHEMBL26116 | — | — | 1 | - |
| CHEMBL86522 | — | — | 1 | - |
| CHEMBL88075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314438 | — | Kd | = | 26915.35 | nM | 4.57 |
| CHEMBL313301 | — | Kd | = | 64565.42 | nM | 4.19 |
| CHEMBL88074 | — | Kd | = | 69183.1 | nM | 4.16 |
| CHEMBL24665 | — | Kd | = | 107151.93 | nM | - |
| CHEMBL26116 | — | Kd | = | 154881.66 | nM | - |
| CHEMBL86522 | — | Kd | = | 114815.36 | nM | - |
| CHEMBL88075 | — | Kd | = | 112201.85 | nM | - |