Assay Detail
Functional
CHEMBL857148
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Inhibition of the contractile responses elicited by sumatriptan in rabbit saphenous vein (RSV)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Saphenous vein |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 7.95 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15928 | GR-127935 | — | 1 | 9.40 |
| CHEMBL15961 | — | — | 1 | 8.70 |
| CHEMBL430122 | — | — | 1 | 8.00 |
| CHEMBL2079627 | — | — | 1 | 7.80 |
| CHEMBL274922 | — | — | 1 | 7.80 |
| CHEMBL15855 | — | — | 1 | 7.70 |
| CHEMBL280000 | — | — | 1 | 7.70 |
| CHEMBL15837 | — | — | 1 | 7.70 |
| CHEMBL16035 | — | — | 1 | 7.70 |
| CHEMBL278917 | — | — | 1 | 7.60 |
| CHEMBL276928 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15928 | GR-127935 | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL15961 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL430122 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL2079627 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL274922 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL15855 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL280000 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL15837 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL16035 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL278917 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL276928 | — | Kd | = | 50.12 | nM | 7.30 |