Assay Detail
Functional
CHEMBL857149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism against A-2 induced contraction of aortic rings from rabbit.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Diphenylpropionic acids as new AT1 selective angiotensin II antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.08 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.53 |
| CHEMBL308659 | — | — | 1 | 8.41 |
| CHEMBL69246 | — | — | 1 | 7.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | Kd | = | 2.951 | nM | 8.53 |
| CHEMBL308659 | — | Kd | = | 3.89 | nM | 8.41 |
| CHEMBL69246 | — | Kd | = | 48.98 | nM | 7.31 |