Assay Detail
Functional
CHEMBL857223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
pA2 value was determined for antidiuretic V2 antagonistic activity in vivo in anesthetized rats pA2 value was determined for antidiuretic V2 antagonistic activity in vivo in anesthetized rats
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Urine |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of potent and selective linear antagonists of vasopressor (V1-receptor) responses to vasopressin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 7.48 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373993 | — | — | 1 | 7.98 |
| CHEMBL2373992 | — | — | 1 | 7.81 |
| CHEMBL2370382 | — | — | 1 | 7.77 |
| CHEMBL2370377 | — | — | 1 | 7.73 |
| CHEMBL387273 | — | — | 1 | 7.69 |
| CHEMBL263860 | — | — | 1 | 7.54 |
| CHEMBL2373370 | — | — | 1 | 7.00 |
| CHEMBL2373442 | — | — | 1 | 6.30 |
| CHEMBL2370378 | — | — | 1 | - |
| CHEMBL2373510 | — | — | 1 | - |
| CHEMBL2373521 | — | — | 1 | - |
| CHEMBL384727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373993 | — | Kd | = | 10.47 | nM | 7.98 |
| CHEMBL2373992 | — | Kd | = | 15.49 | nM | 7.81 |
| CHEMBL2370382 | — | Kd | = | 16.98 | nM | 7.77 |
| CHEMBL2370377 | — | Kd | = | 18.62 | nM | 7.73 |
| CHEMBL387273 | — | Kd | = | 20.42 | nM | 7.69 |
| CHEMBL263860 | — | Kd | = | 28.84 | nM | 7.54 |
| CHEMBL2373370 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL2373442 | — | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL2370378 | — | Kd | ~ | 12.59 | nM | - |
| CHEMBL2373510 | — | Kd | ~ | 141.25 | nM | - |
| CHEMBL2373521 | — | Kd | > | 316.23 | nM | - |
| CHEMBL384727 | — | Kd | ~ | 316.23 | nM | - |