Assay Detail
Functional
CHEMBL857411
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Antiproliferative activity of compound expressed as concentration that inhibits 50% of growth of P388 leukemic cell suspension from 24 to 48 hr after compound addition
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.99 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8670 | — | — | 1 | 6.00 |
| CHEMBL172054 | — | — | 1 | 4.92 |
| CHEMBL8770 | — | — | 1 | 4.77 |
| CHEMBL267060 | — | — | 1 | 4.75 |
| CHEMBL467 | HYDROXYUREA | 4.0 | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8670 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL172054 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL8770 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL267060 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL467 | HYDROXYUREA | IC50 | = | 32000.0 | nM | 4.50 |