Assay Detail
Functional
CHEMBL857412
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In vitro inhibition of platelet aggregation (rabbit) induced by PAF
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design of potent linear PAF antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.21 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115925 | — | — | 1 | 8.29 |
| CHEMBL112926 | — | — | 1 | 8.25 |
| CHEMBL6537 | — | — | 1 | 8.23 |
| CHEMBL113645 | — | — | 1 | 8.12 |
| CHEMBL324229 | — | — | 1 | 8.08 |
| CHEMBL609680 | — | — | 1 | 8.07 |
| CHEMBL116117 | — | — | 1 | 8.06 |
| CHEMBL320719 | — | — | 1 | 8.04 |
| CHEMBL113603 | — | — | 1 | 7.96 |
| CHEMBL113511 | — | — | 1 | 7.96 |
| CHEMBL114623 | — | — | 1 | 7.92 |
| CHEMBL324127 | — | — | 1 | 7.92 |
| CHEMBL274420 | CV-6209 | — | 1 | 7.92 |
| CHEMBL324000 | — | — | 1 | 7.85 |
| CHEMBL115596 | — | — | 1 | 7.82 |
| CHEMBL112262 | — | — | 1 | 7.77 |
| CHEMBL112615 | — | — | 1 | 7.75 |
| CHEMBL322737 | — | — | 1 | 7.75 |
| CHEMBL112672 | — | — | 1 | 7.66 |
| CHEMBL326189 | — | — | 1 | 7.66 |
| CHEMBL113604 | — | — | 1 | 7.64 |
| CHEMBL113610 | — | — | 1 | 7.64 |
| CHEMBL115347 | — | — | 1 | 7.62 |
| CHEMBL332694 | — | — | 1 | 7.58 |
| CHEMBL113133 | — | — | 1 | 7.57 |
| CHEMBL113609 | — | — | 1 | 7.26 |
| CHEMBL111954 | — | — | 1 | 7.14 |
| CHEMBL111807 | — | — | 1 | 6.82 |
| CHEMBL112990 | — | — | 1 | 6.80 |
| CHEMBL115442 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115925 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL112926 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL6537 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL113645 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL324229 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL609680 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL116117 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL320719 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL113603 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL113511 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL324127 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL274420 | CV-6209 | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL114623 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL324000 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL115596 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL112262 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL112615 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL322737 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL112672 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL326189 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL113604 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL113610 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL115347 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL332694 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL113133 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL113609 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL111954 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL111807 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL112990 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL115442 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL269618 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL433196 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL113582 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL320768 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL112432 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL112440 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL422963 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL112473 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL322771 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL419030 | — | IC50 | = | 24000.0 | nM | 4.62 |