Assay Detail
Binding
CHEMBL857690
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Inhibition of binding of radioligand [3H][p-Cl-phe]-DPDPE to Opioid receptor delta 1 in rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.01 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340176 | — | — | 1 | 9.70 |
| CHEMBL340537 | — | — | 1 | 9.40 |
| CHEMBL129252 | — | — | 1 | 9.37 |
| CHEMBL341535 | — | — | 1 | 9.33 |
| CHEMBL339320 | — | — | 1 | 8.85 |
| CHEMBL338462 | — | — | 1 | 8.40 |
| CHEMBL31421 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340176 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL340537 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL129252 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL341535 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL339320 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL338462 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL31421 | — | IC50 | = | 10.0 | nM | 8.00 |