Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL857763

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of contraction of electrically stimulated guinea pig ileum
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Ileum
Confidence 1 — Organism
Curated By Expert

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

Novel analogues of enkephalin: indentification of functional groups required for biological activity.
Gorin FA, Balasubramanian TM, Cicero TJ, Schwietzer J, Marshall GR.
J Med Chem (1980) 23 : 1113 -1122
PubMed 6252322 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.68 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2096625 1 8.80
CHEMBL13767 1 8.05
CHEMBL2369900 1 7.80
CHEMBL340032 DADLE 1 7.77
CHEMBL2369921 1 7.40
CHEMBL14570 1 7.38
CHEMBL13695 1 7.12
CHEMBL274663 1 7.01
CHEMBL2369922 1 6.90
CHEMBL14211 1 6.85
CHEMBL13834 1 6.66
CHEMBL274575 1 6.50
CHEMBL13688 1 6.32
CHEMBL2369909 1 5.85
CHEMBL2369920 1 5.13
CHEMBL2369918 1 5.04
CHEMBL13713 1 5.04
CHEMBL274367 1 4.61

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2096625 IC50 = 1.6 nM 8.80
CHEMBL13767 IC50 = 9.0 nM 8.05
CHEMBL2369900 IC50 = 16.0 nM 7.80
CHEMBL340032 DADLE IC50 = 17.0 nM 7.77
CHEMBL2369921 IC50 = 40.0 nM 7.40
CHEMBL14570 IC50 = 42.0 nM 7.38
CHEMBL13695 IC50 = 75.0 nM 7.12
CHEMBL274663 IC50 = 98.0 nM 7.01
CHEMBL2369922 IC50 = 125.0 nM 6.90
CHEMBL14211 IC50 = 140.0 nM 6.85
CHEMBL13834 IC50 = 220.0 nM 6.66
CHEMBL274575 IC50 = 320.0 nM 6.50
CHEMBL13688 IC50 = 480.0 nM 6.32
CHEMBL2369909 IC50 = 1400.0 nM 5.85
CHEMBL2369920 IC50 = 7330.0 nM 5.13
CHEMBL2369918 IC50 = 9030.0 nM 5.04
CHEMBL13713 IC50 = 9010.0 nM 5.04
CHEMBL274367 IC50 = 24400.0 nM 4.61