Assay Detail
Binding
CHEMBL857791
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Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.19 | 6.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308480 | — | — | 1 | 6.49 |
| CHEMBL310734 | — | — | 1 | 6.42 |
| CHEMBL73675 | — | — | 1 | 6.13 |
| CHEMBL72649 | — | — | 1 | 6.04 |
| CHEMBL310153 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308480 | — | Ki | = | 323.59 | nM | 6.49 |
| CHEMBL310734 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL73675 | — | Ki | = | 741.31 | nM | 6.13 |
| CHEMBL72649 | — | Ki | = | 912.01 | nM | 6.04 |
| CHEMBL310153 | — | Ki | = | 1348.96 | nM | 5.87 |