Assay Detail
Binding
CHEMBL858013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was measured for the inhibition of [3H]ketanserin binding to rat frontal cortex membrane (5-HT2A receptor)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.77 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333174 | — | — | 1 | 8.80 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.12 |
| CHEMBL120903 | — | — | 1 | 8.04 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.70 |
| CHEMBL121744 | — | — | 1 | 6.20 |
| CHEMBL327038 | — | — | 1 | - |
| CHEMBL118947 | — | — | 1 | - |
| CHEMBL118477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333174 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL42 | CLOZAPINE | Ki | = | 7.586 | nM | 8.12 |
| CHEMBL120903 | — | Ki | = | 9.12 | nM | 8.04 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL121744 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL327038 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL118947 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL118477 | — | Ki | < | 10000.0 | nM | - |