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Assay Detail

CHEMBL858019

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The compound was screened in vitro for the displacement of [3H]prazosin binding to bovine Alpha-1A adrenergic receptor
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Alpha-1A adrenergic receptor (CHEMBL4892)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.
Elworthy TR, Ford AP, Bantle GW, Morgans DJ, Ozer RS, Palmer WS, Repke DB, Romero M, Sandoval L, Sjogren EB, Talamás FX, Vazquez A, Wu H, Arredondo NF, Blue DR, DeSousa A, Gross LM, Kava MS, Lesnick JD, Vimont RL, Williams TJ, Zhu QM, Pfister JR, Clarke DE.
J Med Chem (1997) 40 : 2674 -2687
PubMed 9276013 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.10 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL329160 1 9.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL329160 Ki = 0.7943 nM 9.10