Assay Detail
Functional
CHEMBL858093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.55 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336161 | — | — | 1 | 8.28 |
| CHEMBL109783 | — | — | 1 | 8.24 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 6.54 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 5.93 |
| CHEMBL1215 | PHENYLEPHRINE | 4.0 | 1 | 5.78 |
| CHEMBL133451 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336161 | — | EC50 | = | 5.248 | nM | 8.28 |
| CHEMBL109783 | — | EC50 | = | 5.754 | nM | 8.24 |
| CHEMBL762 | OXYMETAZOLINE | EC50 | = | 288.4 | nM | 6.54 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL1215 | PHENYLEPHRINE | EC50 | = | 1659.59 | nM | 5.78 |
| CHEMBL133451 | — | EC50 | = | 30902.95 | nM | 4.51 |