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Assay Detail

CHEMBL858114

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Stomach
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 2B (CHEMBL323)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Photoelectron spectra of psychotropic drugs. 6. Relationships between the physical properties and pharmacological actions of amphetamine analogues.
Domelsmith LN, Eaton TA, Houk KN, Anderson GM, Glennon RA, Shulgin AT, Castagnoli N, Kollman PA.
J Med Chem (1981) 24 : 1414 -1421
PubMed 7310818 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 19 5.94 7.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6607 BROLAMFETAMINE 2.0 1 7.35
CHEMBL8600 DOM 1 7.12
CHEMBL8642 1 6.83
CHEMBL8389 1 6.81
CHEMBL6731 TENAMFETAMINE 2.0 1 6.45
CHEMBL34108 1 6.28
CHEMBL16247 1 5.92
CHEMBL284589 1 5.86
CHEMBL31787 1 5.77
CHEMBL31557 1 5.75
CHEMBL282183 1 5.61
CHEMBL30336 1 5.60
CHEMBL282734 1 5.60
CHEMBL280855 1 5.54
CHEMBL16451 1 5.54
CHEMBL277540 1 5.45
CHEMBL278663 PARA-METHOXYAMPHETAMINE 1 5.16
CHEMBL30577 1 5.09
CHEMBL30777 1 5.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6607 BROLAMFETAMINE Kd = 44.67 nM 7.35
CHEMBL8600 DOM Kd = 75.86 nM 7.12
CHEMBL8642 Kd = 147.91 nM 6.83
CHEMBL8389 Kd = 154.88 nM 6.81
CHEMBL6731 TENAMFETAMINE Kd = 354.81 nM 6.45
CHEMBL34108 Kd = 524.81 nM 6.28
CHEMBL16247 Kd = 1202.26 nM 5.92
CHEMBL284589 Kd = 1380.38 nM 5.86
CHEMBL31787 Kd = 1698.24 nM 5.77
CHEMBL31557 Kd = 1778.28 nM 5.75
CHEMBL282183 Kd = 2454.71 nM 5.61
CHEMBL30336 Kd = 2511.89 nM 5.60
CHEMBL282734 Kd = 2511.89 nM 5.60
CHEMBL280855 Kd = 2884.03 nM 5.54
CHEMBL16451 Kd = 2884.03 nM 5.54
CHEMBL277540 Kd = 3548.13 nM 5.45
CHEMBL278663 PARA-METHOXYAMPHETAMINE Kd = 6918.31 nM 5.16
CHEMBL30577 Kd = 8128.31 nM 5.09
CHEMBL30777 Kd = 8511.38 nM 5.07