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Assay Detail

CHEMBL858250

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Functional
Effective concentration required to produce mechanical response determined in muscle strips of guinea pig
ChEMBL ↗
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Muscle tissue
Confidence 1 — Organism
Curated By Expert

Target

Cavia porcellus (CHEMBL369) ↗
Type ORGANISM
Organism Cavia porcellus

Publication

1,4-Dihydropyridine antagonist activities at the calcium channel: a quantitative structure-activity relationship approach.
Coburn RA, Wierzba M, Suto MJ, Solo AJ, Triggle AM, Triggle DJ.
J Med Chem (1988) 31 : 2103 -2107
PubMed 2846838 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 46 7.01 8.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL307527 — — 1 8.89
CHEMBL66300 — — 1 8.82
CHEMBL63971 — — 1 8.72
CHEMBL63997 — — 1 8.66
CHEMBL25676 — — 1 8.40
CHEMBL24716 — — 1 8.36
CHEMBL63159 — — 1 8.35
CHEMBL193 NIFEDIPINE 4.0 1 8.29
CHEMBL63764 — — 1 8.22
CHEMBL63460 — — 1 8.19
CHEMBL67067 — — 1 8.12
CHEMBL288883 — — 1 8.12
CHEMBL38597 — — 1 7.80
CHEMBL293402 — — 1 7.80
CHEMBL68394 — — 1 7.72
CHEMBL292335 — — 1 7.68
CHEMBL2063842 — — 1 7.55
CHEMBL63315 — — 1 7.52
CHEMBL25312 — — 1 7.46
CHEMBL66621 — — 1 7.38
CHEMBL63030 — — 1 7.37
CHEMBL292515 — — 1 7.33
CHEMBL305316 — — 1 7.24
CHEMBL417734 — — 1 7.13
CHEMBL294371 — — 1 7.03
CHEMBL304041 — — 1 7.00
CHEMBL66840 — — 1 7.00
CHEMBL65085 — — 1 6.96
CHEMBL24419 — — 1 6.96
CHEMBL304522 — — 1 6.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL307527 — EC50 = 1.288 nM 8.89
CHEMBL66300 — EC50 = 1.514 nM 8.82
CHEMBL63971 — EC50 = 1.905 nM 8.72
CHEMBL63997 — EC50 = 2.188 nM 8.66
CHEMBL25676 — EC50 = 3.981 nM 8.40
CHEMBL24716 — EC50 = 4.365 nM 8.36
CHEMBL63159 — EC50 = 4.467 nM 8.35
CHEMBL193 NIFEDIPINE EC50 = 5.129 nM 8.29
CHEMBL63764 — EC50 = 6.026 nM 8.22
CHEMBL63460 — EC50 = 6.457 nM 8.19
CHEMBL67067 — EC50 = 7.586 nM 8.12
CHEMBL288883 — EC50 = 7.586 nM 8.12
CHEMBL293402 — EC50 = 15.85 nM 7.80
CHEMBL38597 — EC50 = 15.85 nM 7.80
CHEMBL68394 — EC50 = 19.05 nM 7.72
CHEMBL292335 — EC50 = 20.89 nM 7.68
CHEMBL2063842 — EC50 = 28.18 nM 7.55
CHEMBL63315 — EC50 = 30.2 nM 7.52
CHEMBL25312 — EC50 = 34.67 nM 7.46
CHEMBL66621 — EC50 = 41.69 nM 7.38
CHEMBL63030 — EC50 = 42.66 nM 7.37
CHEMBL292515 — EC50 = 46.77 nM 7.33
CHEMBL305316 — EC50 = 57.54 nM 7.24
CHEMBL417734 — EC50 = 74.13 nM 7.13
CHEMBL294371 — EC50 = 93.33 nM 7.03
CHEMBL304041 — EC50 = 100.0 nM 7.00
CHEMBL66840 — EC50 = 100.0 nM 7.00
CHEMBL65085 — EC50 = 109.65 nM 6.96
CHEMBL24419 — EC50 = 109.65 nM 6.96
CHEMBL304522 — EC50 = 128.82 nM 6.89
CHEMBL294764 — EC50 = 190.55 nM 6.72
CHEMBL294763 — EC50 = 891.25 nM 6.05
CHEMBL304958 — EC50 = 1000.0 nM 6.00
CHEMBL66111 — EC50 = 1995.26 nM 5.70
CHEMBL1098881 — EC50 = 3162.28 nM 5.50
CHEMBL63425 — EC50 = 3467.37 nM 5.46
CHEMBL63519 — EC50 = 6025.6 nM 5.22
CHEMBL303115 — EC50 = 6309.57 nM 5.20
CHEMBL63260 — EC50 = 8128.31 nM 5.09
CHEMBL63646 — EC50 = 22908.68 nM 4.64
CHEMBL67623 — EC50 = 39810.72 nM 4.40
CHEMBL303436 — EC50 = 50118.72 nM 4.30
CHEMBL2063809 — EC50 = 100000.0 nM 4.00
CHEMBL440867 — EC50 = 1000000.0 nM -
CHEMBL67422 — EC50 = 540.0 nM -
CHEMBL303831 — EC50 = 640.0 nM -