Assay Detail
Binding
CHEMBL858415
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Binding Affinity (pKi) towards human Melatonin receptor type 1B
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.34 | 9.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.53 |
| CHEMBL33700 | — | — | 1 | 8.76 |
| CHEMBL34327 | — | — | 1 | 8.19 |
| CHEMBL33869 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.2951 | nM | 9.53 |
| CHEMBL33700 | — | Ki | = | 1.738 | nM | 8.76 |
| CHEMBL34327 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL33869 | — | Ki | = | 134.9 | nM | 6.87 |