Assay Detail
Binding
CHEMBL858424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibiting [3H]N-Methyl-scopolamine Binding to Muscarinic receptor (M2) in Rat Heart
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M2 (CHEMBL309) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis and biological activity of some 4-DAMP- related compounds
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.64 | 8.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306182 | — | — | 1 | 8.56 |
| CHEMBL76897 | 4-DAMP | — | 1 | 8.40 |
| CHEMBL292857 | — | — | 1 | 7.48 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306182 | — | Ki | = | 2.754 | nM | 8.56 |
| CHEMBL76897 | 4-DAMP | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL292857 | — | Ki | = | 33.11 | nM | 7.48 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 794.33 | nM | 6.10 |