Assay Detail
Binding
CHEMBL858875
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Inhibitory activity against FPPS in Leishmania major
24
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania major |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Farnesyl pyrophosphate synthase (CHEMBL3693) ↗| Type | SINGLE PROTEIN |
| Organism | Leishmania donovani |
Publication
Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.60 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55140 | — | — | 2 | 6.95 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 2 | 6.77 |
| CHEMBL199439 | — | — | 2 | 6.64 |
| CHEMBL53982 | — | — | 2 | 6.38 |
| CHEMBL55886 | — | — | 2 | 5.87 |
| CHEMBL54004 | — | — | 2 | 5.63 |
| CHEMBL199653 | — | — | 2 | 4.96 |
| CHEMBL55371 | — | — | 2 | 4.94 |
| CHEMBL200107 | — | — | 2 | 4.91 |
| CHEMBL202878 | — | — | 2 | 4.54 |
| CHEMBL200262 | — | — | 2 | 4.00 |
| CHEMBL433833 | — | — | 2 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55140 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL55140 | — | IC50 | = | 112.2 | nM | 6.95 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL199439 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL199439 | — | IC50 | = | 229.09 | nM | 6.64 |
| CHEMBL53982 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL53982 | — | IC50 | = | 416.87 | nM | 6.38 |
| CHEMBL55886 | — | IC50 | = | 1348.96 | nM | 5.87 |
| CHEMBL55886 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL54004 | — | IC50 | = | 2344.23 | nM | 5.63 |
| CHEMBL54004 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL199653 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL199653 | — | IC50 | = | 10964.78 | nM | 4.96 |
| CHEMBL55371 | — | IC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL55371 | — | IC50 | = | 11460.0 | nM | 4.94 |
| CHEMBL200107 | — | IC50 | = | 12280.0 | nM | 4.91 |
| CHEMBL200107 | — | IC50 | = | 12302.69 | nM | 4.91 |
| CHEMBL202878 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL202878 | — | IC50 | = | 28840.32 | nM | 4.54 |
| CHEMBL433833 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL200262 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL433833 | — | IC50 | >= | 100000.0 | nM | - |
| CHEMBL200262 | — | IC50 | >= | 100000.0 | nM | - |