Assay Detail
Binding
CHEMBL858889
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Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.89 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL199832 | — | — | 1 | 11.00 |
| CHEMBL49269 | CYCLORPHAN | — | 1 | 10.21 |
| CHEMBL147511 | — | — | 1 | 10.05 |
| CHEMBL203251 | — | — | 1 | 9.80 |
| CHEMBL146756 | — | — | 1 | 9.70 |
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 9.68 |
| CHEMBL199931 | — | — | 1 | 9.66 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 9.64 |
| CHEMBL201271 | — | — | 1 | 9.47 |
| CHEMBL199827 | — | — | 1 | 9.36 |
| CHEMBL200881 | — | — | 1 | 9.19 |
| CHEMBL369919 | — | — | 1 | 9.17 |
| CHEMBL383320 | — | — | 1 | 9.15 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 9.06 |
| CHEMBL193039 | — | — | 1 | 8.66 |
| CHEMBL381750 | — | — | 1 | 8.55 |
| CHEMBL372598 | — | — | 1 | 8.48 |
| CHEMBL49143 | — | — | 1 | 8.43 |
| CHEMBL201220 | — | — | 1 | 8.24 |
| CHEMBL201219 | — | — | 1 | 7.89 |
| CHEMBL372823 | — | — | 1 | 7.85 |
| CHEMBL381117 | — | — | 1 | 7.22 |
| CHEMBL200295 | — | — | 1 | 6.89 |
| CHEMBL201038 | — | — | 1 | 5.96 |
| CHEMBL1790045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL199832 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL49269 | CYCLORPHAN | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL147511 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL203251 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL146756 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL592 | LEVORPHANOL | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL199931 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL201271 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL199827 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL200881 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL369919 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL383320 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL70 | MORPHINE | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL193039 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL381750 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL372598 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL49143 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL201220 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL201219 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL372823 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL381117 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL200295 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL201038 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1790045 | — | Ki | = | 0.003 | nM | - |