Assay Detail
Functional
CHEMBL859172
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.62 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129451 | (-)-CATECHINGALLATE | — | 1 | 5.50 |
| CHEMBL138649 | 6-HYDROXYFLAVONE | — | 1 | 5.28 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 5.09 |
| CHEMBL210692 | — | — | 1 | 5.06 |
| CHEMBL209257 | LADANEIN | — | 1 | 5.05 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.00 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.97 |
| CHEMBL379064 | ISORHAMNETIN | — | 1 | 4.83 |
| CHEMBL348436 | CIRSIMARITIN | — | 1 | 4.77 |
| CHEMBL28 | APIGENIN | — | 1 | 4.76 |
| CHEMBL207954 | — | — | 1 | 4.70 |
| CHEMBL294009 | FLAVONOL | — | 1 | 4.62 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 4.59 |
| CHEMBL117 | CHRYSIN | — | 1 | 4.53 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.52 |
| CHEMBL131921 | BIOCHANIN | — | 1 | 4.46 |
| CHEMBL210411 | — | — | 1 | 4.44 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | 4.42 |
| CHEMBL309490 | GALANGIN | — | 1 | 4.41 |
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 4.40 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | — | 1 | 4.40 |
| CHEMBL441526 | — | — | 1 | 4.39 |
| CHEMBL210276 | 3,7-DIHYDROXYFLAVONE | — | 1 | 4.31 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.24 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 4.22 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | — | 1 | 4.18 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 1 | 4.18 |
| CHEMBL77966 | RETUSIN | — | 1 | 4.13 |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | - |
| CHEMBL129482 | (+)-EPICATECHIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129451 | (-)-CATECHINGALLATE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL138649 | 6-HYDROXYFLAVONE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL31574 | FISETIN | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL210692 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL209257 | LADANEIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL50 | QUERCETIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL379064 | ISORHAMNETIN | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL348436 | CIRSIMARITIN | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL28 | APIGENIN | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL207954 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL294009 | FLAVONOL | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL117 | CHRYSIN | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL131921 | BIOCHANIN | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL210411 | — | IC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL44 | GENISTEIN | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL309490 | GALANGIN | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL36327 | EPICATECHIN GALLATE | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | IC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL441526 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL210276 | 3,7-DIHYDROXYFLAVONE | IC50 | = | 49200.0 | nM | 4.31 |
| CHEMBL164 | MYRICETIN | IC50 | = | 57300.0 | nM | 4.24 |
| CHEMBL275638 | FLAVONE | IC50 | = | 60800.0 | nM | 4.22 |
| CHEMBL16807 | 5-HYDROXYFLAVONE | IC50 | = | 65900.0 | nM | 4.18 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | IC50 | = | 65500.0 | nM | 4.18 |
| CHEMBL77966 | RETUSIN | IC50 | = | 73300.0 | nM | 4.13 |
| CHEMBL28626 | MORIN | IC50 | = | 110400.0 | nM | - |
| CHEMBL264167 | (-)-GALLOCATECHIN | IC50 | > | 150000.0 | nM | - |
| CHEMBL200715 | (-)-CATECHIN | IC50 | > | 150000.0 | nM | - |
| CHEMBL311498 | CIANIDANOL | IC50 | = | 144000.0 | nM | - |
| CHEMBL9352 | NARINGENIN | IC50 | = | 141100.0 | nM | - |
| CHEMBL210635 | GENKWANIN | IC50 | = | 111000.0 | nM | - |
| CHEMBL47386 | EPIGALLOCATECHIN | IC50 | > | 150000.0 | nM | - |
| CHEMBL583912 | (-)-EPICATECHIN | IC50 | > | 150000.0 | nM | - |
| CHEMBL129482 | (+)-EPICATECHIN | IC50 | > | 150000.0 | nM | - |
| CHEMBL8145 | DAIDZEIN | IC50 | = | 103700.0 | nM | - |