Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL210276

3,7-DIHYDROXYFLAVONE
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
O=c1c(O)c(-c2ccccc2)oc2cc(O)ccc12
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL210276
Name 3,7-DIHYDROXYFLAVONE
Phase Preclinical
Structure Type MOL
InChI Key UWQJWDYDYIJWKY-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

254.2
MW (Da)
2.87
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.70
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C15H10O4
MW 254.24
Aromatic Rings 3
Heavy Atoms 19
NP-Likeness 0.95

Activity Summary

IC50 2 meas. best 5.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Enoyl-acyl-carrier protein reductase
CHEMBL4150
 IC50 5.0 5.0 10000.0 1
Plasmodium falciparum
CHEMBL364
 IC50 4.31 4.31 49200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Enoyl-acyl-carrier protein reductase IC50 = 10000.0 nM 5.0 Inhibition of FabI 16722653
Plasmodium falciparum IC50 = 49200.0 nM 4.31 Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 16722653

Literature References

PubMed DOI Target Context # Activities
16722653 10.1021/jm0600545 Plasmodium falciparum 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
21073191 10.1021/jm101206p BDNF/NT-3 growth factors receptor 2
21496973 10.1016/j.ejmech.2011.03.047 MCF7 1
16722653 10.1021/jm0600545 Enoyl-acyl-carrier protein reductase 1
31103904 10.1016/j.ejmech.2019.05.027 ATP-dependent translocase ABCB1 1
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 1
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 1
22300659 10.1016/j.bmcl.2011.12.145 Protein E6 1
16722653 10.1021/jm0600545 Fatty acid synthase 1
21496973 10.1016/j.ejmech.2011.03.047 NON-PROTEIN TARGET 1
21496973 10.1016/j.ejmech.2011.03.047 NCI-H460 1
16722653 10.1021/jm0600545 3-oxoacyl-acyl-carrier protein reductase 1
19944611 10.1016/j.bmc.2009.11.015 NON-PROTEIN TARGET 1
18650094 10.1016/j.bmc.2008.04.067 Dipeptidyl peptidase 4 1
18650094 10.1016/j.bmc.2008.04.067 Prolyl endopeptidase 1
17637507 10.1016/j.bmc.2007.06.025 Serine/threonine-protein kinase pim-1 1
17869117 10.1016/j.bmc.2007.07.036 Polyunsaturated fatty acid lipoxygenase ALOX15B 1
17869117 10.1016/j.bmc.2007.07.036 Polyunsaturated fatty acid lipoxygenase ALOX15 1
17869117 10.1016/j.bmc.2007.07.036 Polyunsaturated fatty acid lipoxygenase ALOX12 1

Data from ChEMBL 36 via Core Engine