Assay Detail
Functional
CHEMBL859173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1
38
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 29 | - | - |
| IC50 | 9 | 5.17 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129451 | (-)-CATECHINGALLATE | — | 1 | 6.40 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | — | 1 | 5.21 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 5.19 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.05 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.02 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 5.00 |
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 4.95 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.89 |
| CHEMBL28626 | MORIN | — | 1 | 4.79 |
| CHEMBL583912 | (-)-EPICATECHIN | 2.0 | 1 | - |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | - |
| CHEMBL441526 | — | — | 1 | - |
| CHEMBL77966 | RETUSIN | — | 1 | - |
| CHEMBL210411 | — | — | 1 | - |
| CHEMBL209257 | LADANEIN | — | 1 | - |
| CHEMBL379064 | ISORHAMNETIN | — | 1 | - |
| CHEMBL9352 | NARINGENIN | — | 1 | - |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | - |
| CHEMBL28 | APIGENIN | — | 1 | - |
| CHEMBL129482 | (+)-EPICATECHIN | 2.0 | 1 | - |
| CHEMBL210635 | GENKWANIN | — | 1 | - |
| CHEMBL200715 | (-)-CATECHIN | — | 1 | - |
| CHEMBL264167 | (-)-GALLOCATECHIN | — | 1 | - |
| CHEMBL131921 | BIOCHANIN | — | 1 | - |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | - |
| CHEMBL8145 | DAIDZEIN | 2.0 | 1 | - |
| CHEMBL207954 | — | — | 1 | - |
| CHEMBL348436 | CIRSIMARITIN | — | 1 | - |
| CHEMBL311498 | CIANIDANOL | 4.0 | 1 | - |
| CHEMBL210692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129451 | (-)-CATECHINGALLATE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL264938 | GALLOCATECHIN GALLATE | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL31574 | FISETIN | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL50 | QUERCETIN | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL36327 | EPICATECHIN GALLATE | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL164 | MYRICETIN | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL28626 | MORIN | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL210411 | — | Activity | - | — | - | |
| CHEMBL210276 | 3,7-DIHYDROXYFLAVONE | Activity | - | — | - | |
| CHEMBL209257 | LADANEIN | Activity | - | — | - | |
| CHEMBL379064 | ISORHAMNETIN | Activity | - | — | - | |
| CHEMBL9352 | NARINGENIN | Activity | - | — | - | |
| CHEMBL150 | KAEMPFEROL | Activity | - | — | - | |
| CHEMBL28 | APIGENIN | Activity | - | — | - | |
| CHEMBL16807 | 5-HYDROXYFLAVONE | Activity | - | — | - | |
| CHEMBL294009 | FLAVONOL | Activity | - | — | - | |
| CHEMBL275638 | FLAVONE | Activity | - | — | - | |
| CHEMBL117 | CHRYSIN | Activity | - | — | - | |
| CHEMBL276915 | 7-HYDROXYFLAVONE | Activity | - | — | - | |
| CHEMBL138649 | 6-HYDROXYFLAVONE | Activity | - | — | - | |
| CHEMBL309490 | GALANGIN | Activity | - | — | - | |
| CHEMBL77966 | RETUSIN | Activity | - | — | - | |
| CHEMBL441526 | — | Activity | - | — | - | |
| CHEMBL47386 | EPIGALLOCATECHIN | Activity | - | — | - | |
| CHEMBL583912 | (-)-EPICATECHIN | Activity | - | — | - | |
| CHEMBL129482 | (+)-EPICATECHIN | Activity | - | — | - | |
| CHEMBL210635 | GENKWANIN | Activity | - | — | - | |
| CHEMBL200715 | (-)-CATECHIN | Activity | - | — | - | |
| CHEMBL264167 | (-)-GALLOCATECHIN | Activity | - | — | - | |
| CHEMBL131921 | BIOCHANIN | Activity | - | — | - | |
| CHEMBL44 | GENISTEIN | Activity | - | — | - | |
| CHEMBL8145 | DAIDZEIN | Activity | - | — | - | |
| CHEMBL207954 | — | Activity | - | — | - | |
| CHEMBL348436 | CIRSIMARITIN | Activity | - | — | - | |
| CHEMBL311498 | CIANIDANOL | Activity | - | — | - | |
| CHEMBL210692 | — | Activity | - | — | - |