Assay Detail
Functional
CHEMBL859585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on degradation of collagen in bovine bone by rabbit osteoclast
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | Osteoclast |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.80 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201782 | — | — | 1 | 7.80 |
| CHEMBL427377 | — | — | 1 | - |
| CHEMBL381135 | — | — | 1 | - |
| CHEMBL201733 | — | — | 1 | - |
| CHEMBL202554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201782 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL427377 | — | IC50 | - | — | - | |
| CHEMBL381135 | — | IC50 | - | — | - | |
| CHEMBL201733 | — | IC50 | - | — | - | |
| CHEMBL202554 | — | IC50 | - | — | - |