Assay Detail
Functional
CHEMBL859670
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Inhibition of LPS-induced IL1-beta production in human whole blood
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.99 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202851 | — | — | 1 | 6.66 |
| CHEMBL203567 | RO-3201195 | 1.0 | 1 | 6.24 |
| CHEMBL380849 | — | — | 1 | 6.16 |
| CHEMBL205133 | — | — | 1 | 6.12 |
| CHEMBL438628 | — | — | 1 | 6.04 |
| CHEMBL203508 | — | — | 1 | 5.92 |
| CHEMBL380850 | — | — | 1 | 5.44 |
| CHEMBL203908 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202851 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL203567 | RO-3201195 | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL380849 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL205133 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL438628 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL203508 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL380850 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL203908 | — | IC50 | = | 4640.0 | nM | 5.33 |