Compound Detail
CHEMBL205133
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Basic Information
| ChEMBL ID | CHEMBL205133 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IJDQETGUEUJVTB-OAHLLOKOSA-N |
1
Targets
3
Activities
1
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
371.4
MW (Da)
1.56
ALogP
7
HBA
3
HBD
110.6
PSA (Ų)
0.54
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 6.7 | 6.2467 | 200.0 | 3 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 3.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 200.0 | nM | 6.7 | Inhibition of LPS-induced TNFalpha production in THP1 cells | 16509574 |
| Mitogen-activated protein kinase 14 | IC50 | = | 760.0 | nM | 6.12 | Inhibition of LPS-induced IL1-beta production in human whole blood | 16509574 |
| Mitogen-activated protein kinase 14 | IC50 | = | 1200.0 | nM | 5.92 | Displacement of [33P] ATP from human recombinant active p38alpha | 16509574 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16509574 | 10.1021/jm050736c | Mitogen-activated protein kinase 14 | 3 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 2 |
| 16509574 | 10.1021/jm050736c | No relevant target | 1 |
| - | 10.6019/CHEMBL3301361 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine