Assay Detail
Binding
CHEMBL859807
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Inhibitory activity against Hsp90 in human breast cancer MDA-MB-468 cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.28 | 7.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 7.99 |
| CHEMBL372962 | — | — | 1 | 7.96 |
| CHEMBL377482 | — | — | 1 | 7.62 |
| CHEMBL199283 | — | — | 1 | 7.52 |
| CHEMBL200001 | — | — | 1 | 7.41 |
| CHEMBL201683 | — | — | 1 | 7.29 |
| CHEMBL383189 | — | — | 1 | 7.26 |
| CHEMBL365159 | — | — | 1 | 7.11 |
| CHEMBL199505 | — | — | 1 | 5.35 |
| CHEMBL372791 | — | — | 1 | - |
| CHEMBL202777 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | EC50 | = | 10.2 | nM | 7.99 |
| CHEMBL372962 | — | EC50 | = | 10.9 | nM | 7.96 |
| CHEMBL377482 | — | EC50 | = | 23.7 | nM | 7.62 |
| CHEMBL199283 | — | EC50 | = | 30.5 | nM | 7.52 |
| CHEMBL200001 | — | EC50 | = | 39.1 | nM | 7.41 |
| CHEMBL201683 | — | EC50 | = | 51.2 | nM | 7.29 |
| CHEMBL383189 | — | EC50 | = | 55.4 | nM | 7.26 |
| CHEMBL365159 | — | EC50 | = | 77.1 | nM | 7.11 |
| CHEMBL199505 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL372791 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL202777 | — | EC50 | > | 15000.0 | nM | - |