Assay Detail
Functional
CHEMBL859861
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Binding affinity to Hsp90 in lung tissue
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Lung |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.52 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 5.66 |
| CHEMBL200001 | — | — | 1 | 5.62 |
| CHEMBL383189 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL200001 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL383189 | — | EC50 | = | 5200.0 | nM | 5.28 |