Assay Detail
Functional
CHEMBL860270
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity mediated by sigma 1 receptor in rat C6 glioma cells by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.70 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190883 | — | — | 1 | 4.97 |
| CHEMBL323056 | — | — | 1 | 4.82 |
| CHEMBL175560 | — | — | 1 | 4.71 |
| CHEMBL176941 | — | — | 1 | 4.59 |
| CHEMBL178326 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190883 | — | EC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL323056 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL175560 | — | EC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL176941 | — | EC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL178326 | — | EC50 | = | 40200.0 | nM | 4.40 |