Assay Detail
Binding
CHEMBL860345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against DPP2
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 4.53 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383841 | — | — | 1 | 5.19 |
| CHEMBL382907 | — | — | 1 | 4.76 |
| CHEMBL425585 | — | — | 1 | 4.72 |
| CHEMBL201544 | — | — | 1 | 4.68 |
| CHEMBL77538 | — | — | 1 | 4.58 |
| CHEMBL372391 | — | — | 1 | 4.53 |
| CHEMBL425756 | — | — | 1 | 4.51 |
| CHEMBL371057 | — | — | 1 | 4.50 |
| CHEMBL201424 | — | — | 1 | 4.47 |
| CHEMBL382847 | — | — | 1 | 4.46 |
| CHEMBL203032 | — | — | 1 | 4.44 |
| CHEMBL307636 | — | — | 1 | 4.40 |
| CHEMBL380902 | — | — | 1 | 4.30 |
| CHEMBL371480 | — | — | 1 | 4.24 |
| CHEMBL98408 | — | — | 1 | 4.16 |
| CHEMBL371907 | — | — | 1 | - |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | - |
| CHEMBL201695 | — | — | 1 | - |
| CHEMBL200103 | — | — | 1 | - |
| CHEMBL424854 | — | — | 1 | - |
| CHEMBL203084 | — | — | 1 | - |
| CHEMBL381530 | — | — | 1 | - |
| CHEMBL372746 | — | — | 1 | - |
| CHEMBL201753 | — | — | 1 | - |
| CHEMBL201158 | — | — | 1 | - |
| CHEMBL201398 | — | — | 1 | - |
| CHEMBL201644 | — | — | 1 | - |
| CHEMBL202711 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383841 | — | IC50 | = | 6452.0 | nM | 5.19 |
| CHEMBL382907 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL425585 | — | IC50 | = | 18869.0 | nM | 4.72 |
| CHEMBL201544 | — | IC50 | = | 20720.0 | nM | 4.68 |
| CHEMBL77538 | — | IC50 | = | 26250.0 | nM | 4.58 |
| CHEMBL372391 | — | IC50 | = | 29315.0 | nM | 4.53 |
| CHEMBL425756 | — | IC50 | = | 31165.0 | nM | 4.51 |
| CHEMBL371057 | — | IC50 | = | 31248.0 | nM | 4.50 |
| CHEMBL201424 | — | IC50 | = | 34201.0 | nM | 4.47 |
| CHEMBL382847 | — | IC50 | = | 34444.0 | nM | 4.46 |
| CHEMBL203032 | — | IC50 | = | 36003.0 | nM | 4.44 |
| CHEMBL307636 | — | IC50 | = | 39873.0 | nM | 4.40 |
| CHEMBL380902 | — | IC50 | = | 50146.0 | nM | 4.30 |
| CHEMBL371480 | — | IC50 | = | 57176.0 | nM | 4.24 |
| CHEMBL98408 | — | IC50 | = | 68985.0 | nM | 4.16 |
| CHEMBL371907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL201695 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL200103 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL424854 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL203084 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL381530 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL372746 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL201753 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL201158 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL201398 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL201644 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL202711 | — | IC50 | > | 100000.0 | nM | - |