Assay Detail
Functional
CHEMBL860814
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A2780 cells
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.82 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438073 | — | — | 1 | 6.73 |
| CHEMBL205786 | — | — | 1 | 6.63 |
| CHEMBL381794 | — | — | 1 | 6.63 |
| CHEMBL426857 | — | — | 1 | 6.48 |
| CHEMBL382364 | — | — | 1 | 6.44 |
| CHEMBL380367 | — | — | 1 | 6.42 |
| CHEMBL205441 | — | — | 1 | 6.40 |
| CHEMBL427386 | — | — | 1 | 6.07 |
| CHEMBL438800 | — | — | 1 | 6.06 |
| CHEMBL207292 | — | — | 1 | 5.92 |
| CHEMBL205928 | — | — | 1 | 5.92 |
| CHEMBL378389 | — | — | 1 | 5.92 |
| CHEMBL205297 | — | — | 1 | 5.73 |
| CHEMBL381062 | — | — | 1 | 5.69 |
| CHEMBL381599 | — | — | 1 | 5.64 |
| CHEMBL205863 | — | — | 1 | 5.62 |
| CHEMBL208309 | — | — | 1 | 5.62 |
| CHEMBL208226 | — | — | 1 | 5.55 |
| CHEMBL206258 | — | — | 1 | 5.54 |
| CHEMBL207601 | — | — | 1 | 5.52 |
| CHEMBL207148 | — | — | 1 | 5.49 |
| CHEMBL377073 | — | — | 1 | 5.46 |
| CHEMBL207973 | — | — | 1 | 5.28 |
| CHEMBL204278 | — | — | 1 | 5.20 |
| CHEMBL207867 | — | — | 1 | 5.14 |
| CHEMBL204372 | — | — | 1 | 5.11 |
| CHEMBL208145 | — | — | 1 | 5.04 |
| CHEMBL205495 | — | — | 1 | - |
| CHEMBL205947 | — | — | 1 | - |
| CHEMBL205864 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438073 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL205786 | — | IC50 | = | 234.0 | nM | 6.63 |
| CHEMBL381794 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL426857 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL382364 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL380367 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL205441 | — | IC50 | = | 402.0 | nM | 6.40 |
| CHEMBL427386 | — | IC50 | = | 851.0 | nM | 6.07 |
| CHEMBL438800 | — | IC50 | = | 879.0 | nM | 6.06 |
| CHEMBL207292 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL205928 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL378389 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL205297 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL381062 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL381599 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL205863 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL208309 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL208226 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL206258 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL207601 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL207148 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL377073 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL207973 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL204278 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL207867 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL204372 | — | IC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL208145 | — | IC50 | = | 9040.0 | nM | 5.04 |
| CHEMBL205099 | — | IC50 | - | — | - | |
| CHEMBL383198 | — | IC50 | - | — | - | |
| CHEMBL206352 | — | IC50 | - | — | - | |
| CHEMBL381553 | — | IC50 | - | — | - | |
| CHEMBL205278 | — | IC50 | - | — | - | |
| CHEMBL382796 | — | IC50 | - | — | - | |
| CHEMBL203681 | — | IC50 | - | — | - | |
| CHEMBL203577 | — | IC50 | - | — | - | |
| CHEMBL382217 | — | IC50 | - | — | - | |
| CHEMBL381061 | — | IC50 | - | — | - | |
| CHEMBL204411 | — | IC50 | - | — | - | |
| CHEMBL377098 | — | IC50 | - | — | - | |
| CHEMBL204371 | — | IC50 | - | — | - | |
| CHEMBL205864 | — | IC50 | - | — | - | |
| CHEMBL205947 | — | IC50 | - | — | - | |
| CHEMBL205495 | — | IC50 | - | — | - |