Assay Detail
Binding
CHEMBL861054
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]deltorphin II from rat delta opioid receptor in brain P2 synaptosomes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.61 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354966 | — | — | 1 | 10.68 |
| CHEMBL109390 | — | — | 1 | 10.46 |
| CHEMBL197183 | — | — | 1 | 9.92 |
| CHEMBL354392 | — | — | 1 | 9.89 |
| CHEMBL422547 | — | — | 1 | 9.80 |
| CHEMBL322300 | — | — | 1 | 9.80 |
| CHEMBL436063 | — | — | 1 | 9.70 |
| CHEMBL317956 | DELTORPHIN C | — | 1 | 9.62 |
| CHEMBL173884 | — | — | 1 | 9.44 |
| CHEMBL278789 | DERMORPHIN | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354966 | — | Ki | = | 0.021 | nM | 10.68 |
| CHEMBL109390 | — | Ki | = | 0.035 | nM | 10.46 |
| CHEMBL197183 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL354392 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL422547 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL322300 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL436063 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL317956 | DELTORPHIN C | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL173884 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL278789 | DERMORPHIN | Ki | = | 178.6 | nM | 6.75 |