Assay Detail
Functional
CHEMBL861108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antithrombotic activity in iv dosed rabbit arterio-venous shunt model
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.64 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436766 | — | — | 1 | 7.30 |
| CHEMBL379036 | — | — | 1 | 6.75 |
| CHEMBL206335 | RAZAXABAN | 2.0 | 1 | 6.47 |
| CHEMBL381949 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436766 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL379036 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL206335 | RAZAXABAN | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL381949 | — | IC50 | = | 920.0 | nM | 6.04 |