Assay Detail
Functional
CHEMBL861464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against PDGF-BB stimulated HCASMC
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.54 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184948 | — | — | 1 | 9.00 |
| CHEMBL120077 | — | — | 1 | 8.52 |
| CHEMBL371949 | — | — | 1 | 8.05 |
| CHEMBL332375 | — | — | 1 | 7.96 |
| CHEMBL120634 | — | — | 1 | 7.80 |
| CHEMBL432219 | — | — | 1 | 7.64 |
| CHEMBL120862 | — | — | 1 | 7.50 |
| CHEMBL121161 | — | — | 1 | 6.91 |
| CHEMBL331760 | — | — | 1 | 6.73 |
| CHEMBL200735 | — | — | 1 | 6.57 |
| CHEMBL371910 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184948 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL120077 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL371949 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL332375 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL120634 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL432219 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL120862 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL121161 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL331760 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL200735 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL371910 | — | IC50 | = | 487.0 | nM | 6.31 |