Compound Detail
CHEMBL332375
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL332375 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SMLHMBXAZLBCAX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
365.4
MW (Da)
3.53
ALogP
6
HBA
2
HBD
85.5
PSA (Ų)
0.53
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 7.96 | 7.72 | 11.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 11.0 | nM | 7.96 | Antiproliferative activity against PDGF-BB stimulated HCASMC | 16366598 |
| Platelet-derived growth factor receptor beta | IC50 | = | 33.0 | nM | 7.48 | Inhibitory activity against PDGFRbeta kinase | 16366598 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16366598 | 10.1021/jm050680m | Platelet-derived growth factor receptor beta | 2 |
Data from ChEMBL 36 via Core Engine