Assay Detail
Functional
CHEMBL861471
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Antiproliferative activity against human breast tumor cell line T47D
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.75 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200735 | — | — | 1 | 7.52 |
| CHEMBL120077 | — | — | 1 | 7.50 |
| CHEMBL120634 | — | — | 1 | 7.48 |
| CHEMBL120862 | — | — | 1 | 7.43 |
| CHEMBL331760 | — | — | 1 | 7.38 |
| CHEMBL432219 | — | — | 1 | 6.38 |
| CHEMBL184948 | — | — | 1 | 6.36 |
| CHEMBL121161 | — | — | 1 | 5.36 |
| CHEMBL371910 | — | — | 1 | 5.33 |
| CHEMBL371949 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200735 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL120077 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL120634 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL120862 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL331760 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL432219 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL184948 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL121161 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL371910 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL371949 | — | IC50 | > | 10000.0 | nM | - |